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Article

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

1 Feb 2010

Abstract excerpt

Most solid tumors are aneuploid, and it has been proposed that aneuploidy is the consequence of an elevated rate of chromosome missegregation in a process called chromosomal instability (CIN). However, the relationship of aneuploidy and CIN is unclear because the proliferation of cultured diploid cells is compromised by chromosome missegregation. The mechanism for this intolerance of nondiploid genomes is...

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PMID: 20123995
DOI: 10.1083/jcb.200905057

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