Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Importance of lymph node immune responses in MSI-H/dMMR colorectal cancer

23 Mar 2021

Abstract excerpt

Patients with colorectal cancers (CRCs) generally exhibit improved survival through intensive lymph node (LN) dissection. However, recent progress in cancer immunotherapy revisits the potential importance of regional LNs, where T cells are primed to attack tumor cells. To elucidate the role of regional LN, we investigated the immunological status of nonmetastatic regional LN lymphocytes (LNLs) in comparison with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Colorectal Cancer Treatments and Studies
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33755600
DOI: 10.1172/jci.insight.137365

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Importance of lymph node immune responses in MSI-H/dMMR colorectal cancerPMID 33755600Read ↗

Genomic and transcriptomic characterization of heterogeneous immune subgroups of microsatellite instability-high colorectal cancers.Semantic proximity Read ↗

Immune Checkpoint Inhibitors in pMMR Metastatic Colorectal Cancer: A Tough ChallengeSemantic proximity Read ↗

Distribution of Regulatory T-Cells and Other Phenotypes of T-Cells in Tumors and Regional Lymph Nodes of Colorectal Cancer Patients.Semantic proximity Read ↗

Effect of RAS mutations and related immune characteristics on the prognosis of patients with MSI-H/dMMR colorectal cancerSemantic proximity Read ↗

Immunotherapy with immune checkpoint inhibitors in colorectal cancer: what is the future beyond deficient mismatch-repair tumours?Semantic proximity Read ↗

A subset of patients with MSS/MSI‑low‑colorectal cancer showed increased CD8(+) TILs together with up‑regulated IFN‑γSemantic proximity Read ↗

Deficient Mismatch Repair and the Role of Immunotherapy in Metastatic Colorectal Cancer.Semantic proximity Read ↗

Immunotherapy efficacy on mismatch repair-deficient colorectal cancer: From bench to bedside.Semantic proximity Read ↗

Crosstalk Between the MSI Status and Tumor Microenvironment in Colorectal Cancer.Semantic proximity Read ↗

Antitumor immunity in dMMR colorectal cancers requires interferon-induced CCL5 and CXCL10Semantic proximity Read ↗

Spatial Dynamics Links PD-L1 and Tumor-Associated Macrophage–Enriched Niches to Immune and Mesenchymal States in Microsatellite Stable Colorectal CancerSemantic proximity Read ↗

Typing the tumor immune signatures in patients of Lynch syndrome facilitates predicting the responsiveness of immune checkpoint inhibitionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.