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Article

Association of MDR1 C3435T and RFC1 G80A polymorphisms with methotrexate toxicity and response in Jordanian rheumatoid arthritis patients.

International journal of clinical pharmacology and therapeutics - 1 Sept 2014

Samara Sima A, Irshaid Yacoub M, Mustafa Khader N

Abstract excerpt

OBJECTIVES: Methotrexate (MTX) is the most commonly used disease-modifying antirheumatic drug for the treatment of rheumatoid arthritis (RA). Genetic polymorphisms of reduced folate carrier (RFC1 G80A) and multi-drug resistance-1 (MDR1 C3435T) might affect MTX response and/or toxicity. The aim of this study was to find out if there is an association between those polymorphisms and MTX toxicity and/or response in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to ATP Binding Cassette Transporter, Subfamily B

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Source

Identifiers

PMID: 25074866
DOI: 10.5414/CP202098

Genes

RFC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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