Molecular alterations in gastric cancer with special reference to the early-onset subtype.

Abstract excerpt

Currently, gastric cancer (GC) is one of the most frequently diagnosed neoplasms, with a global burden of 723000 deaths in 2012. It is the third leading cause of cancer-related death worldwide. There are numerous possible factors that stimulate the pro-carcinogenic activity of important genes. These factors include genetic susceptibility expressed in a single-nucleotide polymorphism, various acquired mutations...

Topics

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• Age of Onset
• Biomarkers, Tumor
• Epigenesis, Genetic
• Gene-Environment Interaction
• Gene Expression Regulation, Neoplastic