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Article

Treatments targeting autophagy ameliorate the age-related macular degeneration phenotype in mice lacking APOE (apolipoprotein E).

Autophagy - 1 Oct 2022

Vessey Kirstan A, Jobling Andrew I, Tran Mai X, Wang Anna Y, Greferath Ursula, Fletcher Erica L

Abstract excerpt

Age-related macular degeneration (AMD) is a leading cause of vision loss with recent evidence indicating an important role for macroautophagy/autophagy in disease progression. In this study we investigate the efficacy of targeting autophagy for slowing dysfunction in a mouse model with features of early AMD. Mice lacking APOE (apolipoprotein E; B6.129P2-Apoetm1UncJ/Arc) and C57BL/6 J- (wild-type, WT) mice were...

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Identifiers

PMID: 35196199
DOI: 10.1080/15548627.2022.2034131
PMCID: PMC9542759

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