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Article

Comparing low-pass sequencing and genotyping for trait mapping in pharmacogenetics.

BMC genomics - 20 Mar 2021

Wasik Kaja, Berisa Tomaz, Pickrell Joseph K, Li Jeremiah H, Fraser Dana J, King Karen, Cox Charles

Abstract excerpt

BACKGROUND: Low pass sequencing has been proposed as a cost-effective alternative to genotyping arrays to identify genetic variants that influence multifactorial traits in humans. For common diseases this typically has required both large sample sizes and comprehensive variant discovery. Genotyping arrays are also routinely used to perform pharmacogenetic (PGx) experiments where sample sizes are likely to be...

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Identifiers

PMID: 33743587
DOI: 10.1186/s12864-021-07508-2
PMCID: PMC7981957

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