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Article

Low-coverage sequencing: implications for design of complex trait association studies.

Genome research - 1 Jun 2011

Li Yun, Sidore Carlo, Kang Hyun Min, Boehnke Michael, Abecasis Gonçalo R

Abstract excerpt

New sequencing technologies allow genomic variation to be surveyed in much greater detail than previously possible. While detailed analysis of a single individual typically requires deep sequencing, when many individuals are sequenced it is possible to combine shallow sequence data across individuals to generate accurate calls in shared stretches of chromosome. Here, we show that, as progressively larger numbers...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21460063
DOI: 10.1101/gr.117259.110
PMCID: PMC3106327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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