Association of genetic variants in CDK6 and XRCC1 with the risk of dysplastic nevi in melanoma-prone families.

doi:10.1038/jid.2013.316

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Article

Association of genetic variants in CDK6 and XRCC1 with the risk of dysplastic nevi in melanoma-prone families.

The Journal of investigative dermatology - 1 Feb 2014

Liang Xueying, Pfeiffer Ruth M, Li Wen-Qing, Brossard Myriam, Burke Laura S, Wheeler William, Calista Donato, Fargnoli Maria Concetta, Ghiorzo Paola, Peris Ketty, Bianchi-Scarra Giovanna, Chaudru Valerie, Zelenika Diana, Maeder Dennis, Burdette Laurie, Yeager Meredith, Chanock Stephen, Landi Maria Teresa, Demenais Florence, Tucker Margaret A, Goldstein Alisa M, Yang Xiaohong R

Abstract excerpt

Dysplastic nevi (DN) is a strong risk factor for cutaneous malignant melanoma (CMM), and it frequently occurs in melanoma-prone families. To identify genetic variants for DN, we genotyped 677 tagSNPs in 38 melanoma candidate genes that are involved in pigmentation, DNA repair, cell cycle control, and melanocyte proliferation pathways in a total of 504 individuals (310 with DN, 194 without DN) from 53...

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Identifiers

PMID: 23892592
DOI: 10.1038/jid.2013.316
PMCID: PMC3873368

Genes

XRCC1
CDK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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