The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene

Abstract excerpt

Male gender is independently and significantly associated with poor prognosis in melanoma of all clinical stages. The biological underpinnings of this sex difference remain largely unknown, but we hypothesized that gene expression from gonosomes (sex chromosomes) might play an important role. We demonstrate that loss of the inactivated X chromosome in melanomas arising in females is strongly associated with poor...

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