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Article

Development of a functional salivary gland tissue chip with potential for high-content drug screening.

Communications biology - 19 Mar 2021

Song Yuanhui, Uchida Hitoshi, Sharipol Azmeer, Piraino Lindsay, Mereness Jared A, Ingalls Matthew H, Rebhahn Jonathan, Newlands Shawn D, DeLouise Lisa A, Ovitt Catherine E, Benoit Danielle S W

Abstract excerpt

Radiation therapy for head and neck cancers causes salivary gland dysfunction leading to permanent xerostomia. Limited progress in the discovery of new therapeutic strategies is attributed to the lack of in vitro models that mimic salivary gland function and allow high-throughput drug screening. We address this limitation by combining engineered extracellular matrices with microbubble (MB) array technology to...

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Identifiers

PMID: 33742114
DOI: 10.1038/s42003-021-01876-x
PMCID: PMC7979686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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