Slow hydrogel matrix degradation enhances salivary gland mimetic phenotype.

doi:10.1016/j.actbio.2023.05.005

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Article

Slow hydrogel matrix degradation enhances salivary gland mimetic phenotype.

Acta biomaterialia - 1 Aug 2023

Mereness Jared A, Piraino Lindsay, Chen Chiao Yun, Moyston Tracey, Song Yuanhui, Shubin Andrew, DeLouise Lisa A, Ovitt Catherine E, Benoit Danielle S W

Abstract excerpt

We recently developed a salivary gland tissue mimetic (SGm), comprised of salivary gland cells encapsulated in matrix metalloproteinase (MMP)-degradable poly(ethylene glycol) hydrogels within arrays of ∼320 µm diameter spherical cavities molded in PDMS. The SGm provides a functional and physiologically relevant platform well-suited to high-throughput drug screening for radioprotective compounds. However, the...

Topics

Hydrogels
Calcium
Salivary Glands
Phenotype
Extracellular Matrix
Peptides
Biocompatible Materials
Polyethylene Glycols

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Identifiers

PMID: 37150277
DOI: 10.1016/j.actbio.2023.05.005
PMCID: PMC10330445

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