Article

Human iPSC-derived salivary gland organoids model diabetic salivary gland dysfunction

2025-10-03

Abstract excerpt

<h4>Summary</h4> Salivary glands are highly susceptible to injury and degeneration. To facilitate studies in human salivary gland disease, we developed a rapid protocol for 3D hiPSC-derived salivary gland organoids that recapitulate human fetal salivary gland gene expression and function, have both ductal and acinar cell types, secretory capacity, and the ability to respond to cholinergic agonism. Oral health iss...

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Literature Corpus work: 290767e7-b1a4-5f3c-88a6-ede35980d5fd
DOI: 10.1101/2025.10.01.679897

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