Article

Assessing Bioactivity and Biointegration of Engineered Salivary Tissue Constructs in a Preclinical Unilateral Fractionated Irradiated Rat Model

2026-05-14

Abstract excerpt

<h4>ABSTRACT</h4> Human salivary stem/progenitor cell (hS/PC)-loaded hyaluronic acid (HA)-based hydrogels, termed 3D-salivary tissue constructs (3D-ST), hold great promise for restoring salivary gland function post-radiation injury. Here, we developed a next-generation 3D-ST using heparin-modified HA and bioactive peptide-modified hydrogels. This new formulation enables controlled pre-loading and localized presen...

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Literature Corpus work: 58f24c9c-a74e-54b6-9494-bac54310509a
DOI: 10.64898/2026.05.11.724009

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