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Article

Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro

19 Mar 2021

Abstract excerpt

The molecular machinery and chromosome structures carrying out meiosis are frequently conserved from yeast to mammals. However, signals initiating meiosis appear divergent: while nutrient restriction induces meiosis in the yeast system, retinoic acid (RA) and its target Stra8 have been shown to be necessary but not sufficient to induce meiotic initiation in mammalian germ cells. Here, we use primary culture of...

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PMID: 33741948
DOI: 10.1038/s41467-021-22021-6

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