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<i>Stra8</i> and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice

17 Sept 2008

Abstract excerpt

In eukaryotes, diploid cells give rise to haploid cells via meiosis, a program of two cell divisions preceded by one round of DNA replication. Although key molecular components of the meiotic apparatus are highly conserved among eukaryotes, the mechanisms responsible for initiating the meiotic program have diverged substantially among eukaryotes. This raises a related question in animals with two distinct sexes:...

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PMID: 18799751
DOI: 10.1073/pnas.0807297105

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