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Identification of destabilizing SNPs in SARS-CoV2-ACE2 protein and spike glycoprotein: implications for virus entry mechanisms.

Journal of biomolecular structure & dynamics - 1 Feb 2022

Khalid Zoya, Naveed Hammad

Abstract excerpt

COVID-19 an outbreak of a novel corona virus originating from Wuhan, China in December 2019 has now spread across the entire world and has been declared a pandemic by WHO. Angiotensin converting enzyme 2 (ACE2) is a receptor protein that interacts with the spike glycoprotein of the host to facilitate the entry of coronavirus (SARS-CoV-2) hence causing the disease (COVID-19). Our experimental design is based on...

Topics

Angiotensin-Converting Enzyme 2
COVID-19
Humans
Molecular Docking Simulation
Polymorphism, Single Nucleotide
Protein Binding
RNA, Viral
SARS-CoV-2
Spike Glycoprotein, Coronavirus
Virus Internalization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32964802
DOI: 10.1080/07391102.2020.1823885
PMCID: PMC7544926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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