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Article

Leishmania donovani chaperonin TCP1γ subunit protects miltefosine induced oxidative damage.

International journal of biological macromolecules - 15 Dec 2020

Yadav Shailendra, Ali Vahab, Singh Yatendra, Kanojia Sanjeev, Goyal Neena

Abstract excerpt

T-complex protein-1 (TCP1) is a chaperonin protein known to fold various proteins like actin and tubulin. In Leishmania donovani only one subunit of TCP1 that is gamma subunit (LdTCP1γ) has been functionally characterized. It not only performs ATP dependent protein folding but is also essential for survival and virulence. The present work demonstrates that LdTCP1γ also has a role in miltefosine resistance....

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PMID: 33736277
DOI: 10.1016/j.ijbiomac.2020.10.134

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