Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Relative influence of heritability, environment and genetics on serum sclerostin.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 Mar 2014

Kuipers A L, Zhang Y, Yu S, Kammerer C M, Nestlerode C S, Chu Y, Bunker C H, Patrick A L, Wheeler V W, Miljkovic I, Zmuda J M

Abstract excerpt

SUMMARY: We determined factors associated with serum sclerostin in 446 Afro-Caribbean family members. Age, weight, sex, diabetes and kidney function were associated with sclerostin. Sclerostin was heritable, and nine SNPs in the SOST gene region were associated with sclerostin. Variation in serum sclerostin is a heritable factor that is determined by both genetic and environmental factors. INTRODUCTION:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Anthropometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Morphogenetic Proteins

Share to Diabetes Mellitus

Share to Gene-Environment Interaction

Share to Glomerular Filtration Rate

Share to Quantitative Trait, Heritable

Share to Sex Characteristics

Source

Open in PubMed Open full text

Identifiers

PMID: 24136102
DOI: 10.1007/s00198-013-2517-0
PMCID: PMC3948173

Genes

SOST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Relative influence of heritability, environment and genetics on serum sclerostin.PMID 24136102Read ↗

Evaluating the correlation of sclerostin levels with obesity and type 2 diabetes in a multiethnic population living in KuwaitSemantic proximity Read ↗

Effect of genetically predicted sclerostin on cardiovascular biomarkers, risk factors, and disease outcomes.Semantic proximity Read ↗

Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a Genome-Wide Association Meta-Analysis Followed by Mendelian Randomization.Semantic proximity Read ↗

Lifelong genetically lowered sclerostin and risk of cardiovascular diseaseSemantic proximity Read ↗

Endocrine functions of sclerostinSemantic proximity Read ↗

The cause-effect relationship between sclerostin levels, cardiovascular biomarkers, risk factors, and cardiovascular diseaseSemantic proximity Read ↗

Methylation of bone SOST, its mRNA, and serum sclerostin levels correlate strongly with fracture risk in postmenopausal women.Semantic proximity Read ↗

A Novel Loss-of-Sclerostin Function Mutation in a First Egyptian Family with Sclerosteosis.Semantic proximity Read ↗

Genetics of Sost/SOST in sclerosteosis and van Buchem disease animal modelsSemantic proximity Read ↗

Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome-wide association meta-analysis followed by Mendelian randomizationSemantic proximity Read ↗

Relationship of sclerostin and secreted frizzled protein polymorphisms with bone mineral density: an association study with replication in postmenopausal women.Semantic proximity Read ↗

SclerostinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.