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Article

Epistasis Detection Based on Epi-GTBN.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021

Chen Xingjian, Wong Ka-Chun

Abstract excerpt

Epistasis detection is a hot topic in bioinformatics due to its relevance to the detection of specific phenotypic traits and gene-gene interactions. Here, we present a step-by-step protocol to apply Epi-GTBN, a machine learning-based method based on genetic algorithm and Bayesian network to effectively mine the epistasis loci. Epi-GTBN utilizes the advantages of genetic algorithm that can achieve a global search...

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PMID: 33733365
DOI: 10.1007/978-1-0716-0947-7_20

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