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Article

High mutation burden in the checkpoint and micro-RNA processing genes in myelodysplastic syndrome.

PloS one - 1 Jan 2021

Moiseev Ivan Sergeevich, Tcvetkov Nikolay Yurevich, Barkhatov Ildar Munerovich, Barabanshikova Maria Vladimirovna, Bug Dmitrii Sergeevich, Petuhova Natalya Vitalievna, Tishkov Artem Valerievich, Bakin Evgenyi Alexandrovich, Izmailova Ekaterina Andreevna, Shakirova Alena Igorevna, Kulagin Alexandr Dmitrievich, Morozova Elena Vladislavovna

Abstract excerpt

A number of sequencing studies identified the prognostic impact of somatic mutations in myelodysplastic syndrome (MDS). However the majority of them focused on methylation regulation, apoptosis and proliferation genes. Despite the number of experimental studies published on the role of micro-RNA processing and checkpoint genes in the development of MDS, the clinical data about mutational landscape in these genes...

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Identifiers

PMID: 33730109
DOI: 10.1371/journal.pone.0248430
PMCID: PMC7968630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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