Article
Mutated genes and driver pathways involved in myelodysplastic syndromes—a transcriptome sequencing based approach.
Molecular bioSystems - 1 Aug 2015
Liu Liang, Wang Hongyan, Wen Jianguo, Tseng Chih-En, Zu Youli, Chang Chung-che, Zhou Xiaobo
Abstract excerpt
Myelodysplastic syndromes are a heterogeneous group of clonal disorders of hematopoietic progenitors and have potentiality to progress into acute myelogenous leukemia. Development of effective treatments has been impeded by limited insight into pathogenic pathways. In this study, we applied RNA-seq technology to study the transcriptome on 20 MDS patients and 5 age-matched controls, and developed a pipeline for...
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