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Article

BRAF-mutated histiocytosis of the skull lacking the expression of Langerhans cell markers.

Clinical neuropathology - 1 Jan 2000

El Sissy Franck-Neil, Lorillon Gwenael, Mandonnet Emmanuel, Polivka Marc, Addle-Biassette Homa, Emile Jean-François

Abstract excerpt

Langerhans cell histiocytosis (LCH) is a rare condition affecting children more frequently than adults. LCH can involve any organ in the body and has a wide spectrum of clinical presentation from a single self-healing bone lesion to a multisystemic life-threatening disease. The diagnosis of LCH requires histology with compatible clinical and radiological findings. Positive immunochemistry for both CD1a and CD207...

Topics

Biomarkers
Bone Diseases
Histiocytosis, Langerhans-Cell
Humans
Male
Middle Aged
Mutation
Proto-Oncogene Proteins B-raf
Skull

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 31661070
DOI: 10.5414/NP301225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-31661070-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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