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Article

The impact of mitochondria-related POLG and TFAM variants on breast cancer pathomorphological characteristics and patient outcomes.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Jun 2021

Golubickaite Ieva, Ugenskiene Rasa, Korobeinikova Erika, Gudaitiene Jurgita, Vaitiekus Domas, Poskiene Lina, Juozaityte Elona

Abstract excerpt

PURPOSE: Breast cancer is the most frequent female cancer, leading to relapse with distant metastasis of approximately one-third of patients. Cancer is usually considered a genetic disease involving mutations in nuclear DNA. However, genes, coding for mitochondrial proteins or regulatory molecules, are rarely under consideration. This study aimed to analyse 10 single nucleotide variants in POLG and TFAM genes and...

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Identifiers

PMID: 33715547
DOI: 10.1080/1354750X.2021.1900397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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