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Mitochondria-Related TFAM and POLG Gene Variants and Associations with Tumor Characteristics and Patient Survival in Head and Neck Cancer.

Genes - 8 Feb 2023

Golubickaite Ieva, Ugenskiene Rasa, Bartnykaite Agne, Poskiene Lina, Vegiene Aurelija, Padervinskis Evaldas, Rudzianskas Viktoras, Juozaityte Elona

Abstract excerpt

In 2020, 878,348 newly reported cases and 444,347 deaths related to head and neck cancer were reported. These numbers suggest that there is still a need for molecular biomarkers for the diagnosis and prognosis of the disease. In this study, we aimed to analyze mitochondria-related mitochondrial transcription factor A (TFAM) and DNA polymerase γ (POLG) single-nucleotide polymorphisms (SNPs) in the head and neck...

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Identifiers

PMID: 36833361
DOI: 10.3390/genes14020434
PMCID: PMC9956916

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