Article
A new reliable and highly specific monoclonal antibody to detect the C-terminal region of silencer of cytokine signaling 1.
European journal of haematology - 1 Jul 2021
Weissinger Stephanie E, Zahn Malena, Marienfeld Ralf, Tessmer Claudia, Moldenhauer Gerhard, Möller Peter
Abstract excerpt
INTRODUCTION: SOCS1, a negative regulator of JAK/STAT signaling, is among the most frequently mutated genes in DLBCL and classical Hodgkin lymphoma. The C-terminal SOCS box domain, mediating the degradation of phospho-JAK2, is often affected or even lacking. The analysis of such variants is hampered by the lack of a SOCS1-specific monoclonal antibody recognizing the C-terminus of SOCS1. As this C-terminus is...
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