Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Survivin drives tumor-associated macrophage reprogramming: a novel mechanism with potential impact for obesity.

Cellular oncology (Dordrecht, Netherlands) - 1 Aug 2021

Benaiges E, Ceperuelo-Mallafré V, Madeira A, Bosch R, Núñez-Roa C, Ejarque M, Maymó-Masip E, Huber-Ruano I, Lejeune M, Vendrell J, Fernández-Veledo S

Abstract excerpt

PURPOSE: Recent studies point to adipose-derived stem cells (ASCs) as a link between obesity and cancer. We aimed to determine whether survivin, which is highly secreted by ASCs from subjects with obesity, might drive a pro-tumoral phenotype in macrophages. METHODS: The effect of ASC conditioned medium on the macrophage phenotype was assessed by expression studies. Survivin intracellular localization and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue
Share to Caco-2 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hep G2 Cells

Share to HT29 Cells

Share to Survivin

Share to THP-1 Cells

Share to Tumor-Associated Macrophages

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 33710603
DOI: 10.1007/s13402-021-00597-x
PMCID: PMC8338861

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Survivin drives tumor-associated macrophage reprogramming: a novel mechanism with potential impact for obesity.PMID 33710603Read ↗

The intricate role of adipokines in cancer-related signaling and the tumor microenvironment: Insights for future researchSemantic proximity Read ↗

Adipose tissue macrophages: implications for obesity-associated cancerSemantic proximity Read ↗

Adipocyte mesenchymal transition contributes to mammary tumor progressionSemantic proximity Read ↗

Tumor Metabolic Reprogramming by Adipokines as a Critical Driver of Obesity-Associated Cancer Progression.Semantic proximity Read ↗

Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity.Semantic proximity Read ↗

Human adipose tissue macrophages display activation of cancer-related pathways.Semantic proximity Read ↗

Obesity modifies cell fate plasticity of Pdgfrα-expressing adipocyte progenitors to promote an aberrant mammary microenvironmentSemantic proximity Read ↗

Cellular mechanisms linking cancers to obesitySemantic proximity Read ↗

p53 deficient breast cancer cells reprogram preadipocytes toward tumor-protective immunomodulatory cellsSemantic proximity Read ↗

Delivery of Adipose-Derived Stem Cells Attenuates Adipose Tissue Inflammation and Insulin Resistance in Obese Mice Through Remodeling Macrophage Phenotypes.Semantic proximity Read ↗

Metabolically activated macrophages in mammary adipose tissue link obesity to triple-negative breast cancerSemantic proximity Read ↗

Adipose stem cells control obesity-induced T cell infiltration into adipose tissueSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.