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Developmental Progression to Infectivity in <i>Trypanosoma brucei</i> Triggered by an RNA-Binding Protein

6 Dec 2012

Abstract excerpt

Unraveling the intricate interactions between Trypanosoma brucei, the protozoan parasite causing African trypanosomiasis, and the tsetse (Glossina) vector remains a challenge. Metacyclic trypanosomes, which inhabit the tsetse salivary glands, transmit the disease and are produced through a complex differentiation and unknown program. By overexpressing a single RNA-binding protein, TbRBP6, in cultured...

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PMID: 23224556
DOI: 10.1126/science.1229641

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