Article
Theragnostic chromosomal rearrangements in treatment-naive pancreatic ductal adenocarcinomas obtained via endoscopic ultrasound.
Journal of cellular and molecular medicine - 1 Apr 2021
Murphy Stephen J, Levy Michael J, Smadbeck James B, Karagouga Giannoula, McCune Alexa F, Harris Faye R, Udell Julia B, Johnson Sarah H, Kerr Sarah E, Cheville John C, Kipp Benjamin R, Vasmatzis George, Gleeson Ferga C
Abstract excerpt
A crucial mutational mechanism in malignancy is structural variation, in which chromosomal rearrangements alter gene functions that drive cancer progression. Herein, the presence and pattern of structural variations were investigated in twelve prospectively acquired treatment-naïve pancreatic cancers specimens obtained via endoscopic ultrasound (EUS). In many patients, this diagnostic biopsy procedure and...
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