Article
Genomic profiling amplifies the utility of endoscopic ultrasound-guided fine needle biopsy by identifying clinically applicable druggable mutations in pancreatic cancer.
Annals of diagnostic pathology - 1 Oct 2022
Ohyama Hiroshi, Mikata Rintaro, Hirotsu Yosuke, Amemiya Kenji, Miura Yoshifumi, Hirose Sumio, Oyama Toshio, Takano Atsushi, Iimuro Yuji, Kojima Yuichiro, Mochizuki Hitoshi, Ikeda Junichiro, Kato Naoya, Omata Masao
Abstract excerpt
BACKGROUND: Genomic profiling of tumors is available, but whether the small fragment obtained via endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) is sufficient for these examinations is unknown. Here we investigated whether EUS-FNB specimens are suitable for genomic profiling to identify oncogenic and drug-matched mutations. METHODS: We constructed a pancreatobiliary cancer panel for targeted panel...
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