Article
An Asian-specific MPL genetic variant alters JAK-STAT signaling and influences platelet count in the population.
Human molecular genetics - 28 May 2021
Sun Pengfei, Zhou Wei, Fu Yi, Cheung Chloe Y Y, Dong Yujun, Yang Min-Lee, Zhang He, Jia Jia, Huo Yong, Willer Cristen J, Chen Y Eugene, Tang Clara S, Tse Hung-Fat, Lam Karen S L, Gao Wei, Xu Ming, Yu Haiyi, Sham Pak Chung, Zhang Yan, Ganesh Santhi K
Abstract excerpt
Genomic discovery efforts for hematological traits have been successfully conducted through genome-wide association study on samples of predominantly European ancestry. We sought to conduct unbiased genetic discovery for coding variants that influence hematological traits in a Han Chinese population. A total of 5257 Han Chinese subjects from Beijing, China were included in the discovery cohort and analyzed by an...
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