Article
Genetic association between germline JAK2 polymorphisms and myeloproliferative neoplasms in Hong Kong Chinese population: a case-control study.
BMC genetics - 20 Dec 2014
Koh Su Pin, Yip Shea Ping, Lee Kwok Kuen, Chan Chi Chung, Lau Sze Man, Kho Chi Shan, Lau Chi Kuen, Lin Shek Ying, Lau Yat Ming, Wong Lap Gate, Au Ka Leung, Wong Kit Fai, Chu Raymond W, Yu Pui Hung, Chow Eudora Y D, Leung Kate F S, Tsoi Wai Chiu, Yung Benjamin Y M
Abstract excerpt
BACKGROUND: Myeloproliferative neoplasms (MPNs) are a group of haematological malignancies that can be characterised by a somatic mutation (JAK2V617F). This mutation causes the bone marrow to produce excessive blood cells and is found in polycythaemia vera (~95%), essential thrombocythaemia and primary myelofibrosis (both ~50%). It is considered as a major genetic factor contributing to the development of these...
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