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Article

Adipocyte-derived microvesicles from obese mice induce M1 macrophage phenotype through secreted miR-155.

Journal of molecular cell biology - 1 Dec 2016

Zhang Yaqin, Mei Hongliang, Chang Xiaoai, Chen Fang, Zhu Yunxia, Han Xiao

Abstract excerpt

The pro-inflammatory profile of M1 macrophage accumulation in adipose tissue is a central event leading to the metabolic complications of obesity. However, the mechanisms by which M1 macrophages are enriched in adipose tissue during weight gain remain incompletely understood. Here, we investigated the effects of adipocyte-derived microvesicles (ADM) on modulating macrophage phenotype in mice and explored the...

Read the complete abstract on PubMed

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Share to Adipocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Diet, High-Fat

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Source

Identifiers

PMID: 27671445
DOI: 10.1093/jmcb/mjw040

Genes

ADM
SOCS1
STAT1
STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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