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IL4I1-driven AHR signature: a new avenue for cancer therapy

10 Mar 2021

Abstract excerpt

Aryl hydrocarbon receptor (AHR) was considered to be an important pan-tumor therapeutic target, but small molecule inhibitors targeting AHR target gene IDO1 have failed in clinical trials. The recent paper published in Cell by Opitz et al. explained the failure of previous clinical trials and identified new therapeutic targets 1 (Fig. 1 ). Fig. 1 Newly identified IL4I1 which is induced by immune checkpoint...

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PMID: 33692337
DOI: 10.1038/s41392-021-00529-z

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