Article
Clonal evolution in chronic lymphocytic leukemia is scant in relapsed but accelerated in refractory cases after chemo(immune) therapy.
Haematologica - 1 Mar 2022
Zapatka Marc, Tausch Eugen, Öztürk Selcen, Yosifov Deyan Yordanov, Seiffert Martina, Zenz Thorsten, Schneider Christof, Blöhdorn Johannes, Döhner Hartmut, Mertens Daniel, Lichter Peter, Stilgenbauer Stephan
Abstract excerpt
Clonal evolution is involved in the progression of chronic lymphocytic leukemia (CLL). In order to link evolutionary patterns to different disease courses, we performed a long-term longitudinal mutation profiling study of CLL patients. Tracking somatic mutations and their changes in allele frequency over time and assessing the underlying cancer cell fraction revealed highly distinct evolutionary patterns....
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