Article
Phenotypic characterization of Adig null mice suggests roles for adipogenin in the regulation of fat mass accrual and leptin secretion.
Cell reports - 9 Mar 2021
Alvarez-Guaita Anna, Patel Satish, Lim Koini, Haider Afreen, Dong Liang, Conway Olivia J, Ma Marcella K L, Chiarugi Davide, Saudek Vladimir, O'Rahilly Stephen, Savage David B
Abstract excerpt
Adipogenin (Adig) is an adipocyte-enriched transmembrane protein. Its expression is induced during adipogenesis in rodent cells, and a recent genome-wide association study associated body mass index (BMI)-adjusted leptin levels with the ADIG locus. In order to begin to understand the biological function of Adig, we studied adipogenesis in Adig-deficient cultured adipocytes and phenotyped Adig null (Adig-/-) mice....
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