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Article

Total number of reads affects the accuracy of fetal fraction estimates in NIPT.

Molecular genetics & genomic medicine - 1 Apr 2021

Miceikaitė Ieva, Brasch-Andersen Charlotte, Fagerberg Christina, Larsen Martin Jakob

Abstract excerpt

BACKGROUND: Sufficient fetal fraction (FF) is crucial for quality control of NIPT (Non-Invasive Prenatal Test) results. Different factors influencing bioinformatic estimation of FF should be considered when implementing NIPT. To what extent the total number of sequencing reads influences FF estimate has been unexplored. In this study, to test the robustness of SeqFF FF estimation and provide additional...

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Identifiers

PMID: 33687149
DOI: 10.1002/mgg3.1653
PMCID: PMC8123752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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