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Article

A stalled-ribosome rescue factor Pth3 is required for mitochondrial translation against antibiotics in Saccharomyces cerevisiae.

Communications biology - 8 Mar 2021

Hoshino Soichiro, Kanemura Ryohei, Kurita Daisuke, Soutome Yukihiro, Himeno Hyouta, Takaine Masak, Watanabe Masakatsu, Nameki Nobukazu

Abstract excerpt

Mitochondrial translation appears to involve two stalled-ribosome rescue factors (srRFs). One srRF is an ICT1 protein from humans that rescues a "non-stop" type of mitochondrial ribosomes (mitoribosomes) stalled on mRNA lacking a stop codon, while the other, C12orf65, reportedly has functions that overlap with those of ICT1; however, its primary role remains unclear. We herein demonstrated that the Saccharomyces...

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Identifiers

PMID: 33686140
DOI: 10.1038/s42003-021-01835-6
PMCID: PMC7940416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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