Article
Overexpressed ribosomal proteins suppress defective chaperonins in Saccharomyces cerevisiae.
FEMS yeast research - 1 Dec 2008
Kabir M Anaul, Sherman Fred
Abstract excerpt
The chaperonin Cct complex of the yeast Saccharomyces cerevisiae is composed of eight different subunits encoded by eight essential genes, CCT1-CCT8. This Cct complex is responsible for the folding of a number of proteins including actin and tubulin. We have isolated and characterized 22 multicopy suppressors of the temperature-sensitive allele, cct4-1, which encodes an altered protein with a G345D replacement...
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