Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biallelic mutations in ANAPC13 cause female infertility characterized by oocyte maturation arrest both in humans and mice.

American journal of obstetrics and gynecology - 1 Sept 2026

Wang Yu, Ding Zhiming, Liu Xuemei, Liu Xu, Tan Hujia, Zheng Na, Yu Kexin, Chen Biaobang, Wang Fengsong, Cao Yunxia, Huang Lingli, Sang Qing, Zhu Fuxi

Abstract excerpt

BACKGROUND: Oocyte maturation arrest is an intractable clinical problem, resulting in recurrent failure of assisted reproductive treatments. The anaphase-promoting complex or cyclosome orchestrates a series of proteolytic events to ensure proper cell cycle progression of mitosis in somatic cell proliferation and meiosis during oocyte maturation. Defects in anaphase-promoting complex or cyclosome subunits, such as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Anaphase-Promoting Complex-Cyclosome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infertility, Female

Share to Mutation

Share to Oocytes

Source

Identifiers

PMID: 41997520
DOI: 10.1016/j.ajog.2026.04.017

Genes

ANAPC13

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biallelic mutations in ANAPC13 cause female infertility characterized by oocyte maturation arrest both in humans and mice.PMID 41997520Read ↗

RGS12 as a Novel Maternal-Effect Gene Causes Arrest at the Pronuclear Stage of Human ZygoteSemantic proximity Read ↗

Gene Spectrum and Clinical Traits of Nine Patients With Oocyte Maturation ArrestSemantic proximity Read ↗

Novel mutations in TRIP13 lead to female infertility with oocyte maturation arrest.Semantic proximity Read ↗

Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic developmentSemantic proximity Read ↗

Novel mutations in PATL2 cause female infertility with oocyte germinal vesicle arrestSemantic proximity Read ↗

Mutations in CCNB3 affect its location thus causing a multiplicity of phenotypes in human oocytes maturation by aberrant CDK1 activity and APC/C activity at different stages.Semantic proximity Read ↗

Biallelic variants in MAD2L1BP (p31comet) cause female infertility characterized by oocyte maturation arrestSemantic proximity Read ↗

Novel PATL2 variants cause female infertility with oocyte maturation defect.Semantic proximity Read ↗

Bi-allelic Missense Pathogenic Variants in TRIP13 Cause Female Infertility Characterized by Oocyte Maturation Arrest.Semantic proximity Read ↗

Infertile females with biallelic mutations in APC/C genes are characterized by oocyte or early embryo defects.Semantic proximity Read ↗

Oocyte maturation arrest produced by TUBB8 mutations: impact of genetic disorders in infertility treatment.Semantic proximity Read ↗

PATL2 is a key actor of oocyte maturation whose invalidation causes infertility in women and miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.