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Article

Studying APOE ɛ4 Allele Dose Effects with a Univariate Morphometry Biomarker.

Journal of Alzheimer's disease : JAD - 1 Jan 2022

Wang Gang, Zhou Wenju, Kong Deping, Qu Zongshuai, Ba Maowen, Hao Jinguang, Yao Tao, Dong Qunxi, Su Yi, Reiman Eric M, Caselli Richard J, Chen Kewei, Wang Yalin

Abstract excerpt

BACKGROUND: A univariate neurodegeneration biomarker (UNB) based on MRI with strong statistical discrimination power would be highly desirable for studying hippocampal surface morphological changes associated with APOE ɛ4 genetic risk for AD in the cognitively unimpaired (CU) population. However, existing UNB work either fails to model large group variances or does not capture AD induced changes. OBJECTIVE: We...

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Identifiers

PMID: 34924383
DOI: 10.3233/JAD-215149
PMCID: PMC10498787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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