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Article

Human protein N-terminal acetyltransferase hNaa50p (hNAT5/hSAN) follows ordered sequential catalytic mechanism: combined kinetic and NMR study.

The Journal of biological chemistry - 23 Mar 2012

Evjenth Rune H, Brenner Annette K, Thompson Paul R, Arnesen Thomas, Frøystein Nils Åge, Lillehaug Johan R

Abstract excerpt

N(α)-acetylation is a common protein modification catalyzed by different N-terminal acetyltransferases (NATs). Their essential role in the biogenesis and degradation of proteins is becoming increasingly evident. The NAT hNaa50p preferentially modifies peptides starting with methionine followed by a hydrophobic amino acid. hNaa50p also possesses N(ε)-autoacetylation activity. So far, no eukaryotic NAT has been...

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Identifiers

PMID: 22311970
DOI: 10.1074/jbc.M111.326587
PMCID: PMC3323058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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