Article
Characterization of Arylalkylamine N-Acyltransferase from Tribolium castaneum: An Investigation into a Potential Next-Generation Insecticide Target.
ACS chemical biology - 21 Feb 2020
O'Flynn Brian G, Lewandowski Eric M, Prins Karin Claire, Suarez Gabriela, McCaskey Angelica N, Rios-Guzman Nasha M, Anderson Ryan L, Shepherd Britney A, Gelis Ioannis, Leahy James W, Chen Yu, Merkler David J
Abstract excerpt
The growing issue of insecticide resistance has meant the identification of novel insecticide targets has never been more important. Arylalkylamine N-acyltransferases (AANATs) have been suggested as a potential new target. These promiscuous enzymes are involved in the N-acylation of biogenic amines to form N-acylamides. In insects, this process is a key step in melanism, hardening of the cuticle, removal of...
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