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Article

First genome-wide association study on rocuronium dose requirements shows association with SLCO1A2.

British journal of anaesthesia - 1 May 2021

Ahlström Sirkku, Bergman Paula, Jokela Ritva, Ottensmann Linda, Ahola-Olli Ari, Pirinen Matti, Olkkola Klaus T, Kaunisto Mari A, Kalso Eija

Abstract excerpt

BACKGROUND: Rocuronium, a common neuromuscular blocking agent, is mainly excreted unchanged in urine (10-25%) and bile (>70%). Age, sex, liver blood flow, smoking, medical conditions, and ethnic background can affect its pharmacological actions. However, reasons for the wide variation in rocuronium requirements are mostly unknown. We hypothesised that pharmacogenetic factors might explain part of the variation....

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Source

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Identifiers

PMID: 33676726
DOI: 10.1016/j.bja.2021.01.029
PMCID: PMC8132880

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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