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Article

Association of CYP450 single nucleotide polymorphisms with the efficacy of epidural ropivacaine during mastectomy.

Acta anaesthesiologica Scandinavica - 1 May 2015

Liu J, Xi H, Jiang Y, Feng Z, Hou L, Li W

Abstract excerpt

BACKGROUND: Ropivacaine is frequently used for local anesthesia in the clinic and is metabolized by cytochrome P450 (CYP450) in the liver. CYP450 polymorphisms may alter the therapeutic efficacy of drugs in patients. In this study, we selected six CYP450 polymorphisms from the dbSNP and HapMap databases, using a combination of functional analysis and Tag SNP strategies and examined these polymorphisms for...

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Identifiers

PMID: 25808509
DOI: 10.1111/aas.12501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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