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Article

Polymorphisms contribute to differences in the effect of rocuronium in Chinese patients.

Basic & clinical pharmacology & toxicology - 1 Jan 2022

Zhu Hongyu, Wang Yafeng, Wang Qi, Zhao Shuai, Xu Feng, Hu Zhiqiang, Zhou Ruihui, Huang Shiqian, Han Linlin, Chen Xiangdong

Abstract excerpt

Rocuronium is widely utilized in clinical general anaesthesia, and individual differences in pharmacology and clearance have been observed. Two hundred thirty-six Chinese patients undergoing selective thyroid/breast mass resection were studied. Total intravenous anaesthesia was induced with a single dose of propofol (2 mg·kg-1 ), sufentanil (0.5 μg·kg-1 ), and rocuronium (0.6 mg·kg-1 ) and maintained with...

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PMID: 34734679
DOI: 10.1111/bcpt.13682

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