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Article

APOL1 variant alleles associate with reduced risk for opportunistic infections in HIV infection.

Communications biology - 5 Mar 2021

An Ping, Sezgin Efe, Kirk Gregory D, Duggal Priya, Binns-Roemer Elizabeth, Nelson George, Limou Sophie, Van Natta Mark L, Jabs Douglas A, Estrella Michelle, Kopp Jeffrey B, Winkler Cheryl A

Abstract excerpt

Apolipoprotein L1 (APOL1), an innate immune factor against African trypanosoma brucei, inhibits HIV-1 in vitro. The impact of APOL1 G1-G2 variants on HIV-1-associated opportunistic infections (OIs) is unknown. Here, we report findings from a metaanalysis of four HIV/AIDS prospective cohorts (ALIVE, LSOCA, MACS, and WIHS) including 2066 African American participants. Using a global test combining all four cohorts,...

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Identifiers

PMID: 33674766
DOI: 10.1038/s42003-021-01812-z
PMCID: PMC7977062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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