Article
Parallel molecular mechanisms for enzyme temperature adaptation.
Science (New York, N.Y.) - 5 Mar 2021
Pinney Margaux M, Mokhtari Daniel A, Akiva Eyal, Yabukarski Filip, Sanchez David M, Liang Ruibin, Doukov Tzanko, Martinez Todd J, Babbitt Patricia C, Herschlag Daniel
Abstract excerpt
The mechanisms that underly the adaptation of enzyme activities and stabilities to temperature are fundamental to our understanding of molecular evolution and how enzymes work. Here, we investigate the molecular and evolutionary mechanisms of enzyme temperature adaption, combining deep mechanistic studies with comprehensive sequence analyses of thousands of enzymes. We show that temperature adaptation in...
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