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Diagnostic Performance of Commercial Antithrombin Activity Assays: Do We Get What We Expect?

Thrombosis and haemostasis - 1 Apr 2026

Orlando Christelle, Drèze Céline, Evenepoel Anton, Seneca Sara, Jochmans Kristin

Abstract excerpt

Hereditary antithrombin (AT) deficiency is a rare autosomal dominant disorder that predisposes to the development of recurrent venous thromboembolism (VTE). Diagnosis is based on the measurement of reduced AT activity in plasma. However, not all commercial AT activity assays are equally suited for diagnosis since they differ in sensitivity toward different AT mutations.The aim of this study was to compare the...

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PMID: 40473262
DOI: 10.1055/a-2628-4046
PMCID: PMC13008483

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