Thrombin inhibition profiles in healthy individuals and thrombophilic patients.

doi:10.1160/TH11-10-0719

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Article

Thrombin inhibition profiles in healthy individuals and thrombophilic patients.

Thrombosis and haemostasis - 1 May 2012

Rühl Heiko, Müller Jens, Harbrecht Ursula, Fimmers Rolf, Oldenburg Johannes, Mayer Günter, Pötzsch Bernd

Abstract excerpt

Inhibition of thrombin by endogenous inhibitors plays a central role in the spatiotemporal control of clot formation. A failure to adequately inactivate thrombin such as in antithrombin deficiency generates a strong prothrombotic phenotype. To study if and to what extent delayed thrombin inactivation rates beyond antithrombin deficiency contribute to the prothrombotic phenotype we measured thrombin inhibition...

Topics

Adult
Aged
Antibodies, Antiphospholipid
Antiphospholipid Syndrome
Antithrombin Proteins
Antithrombins
Arginine
Blood Coagulation
Blood Coagulation Tests
Case-Control Studies
Female
Germany
Half-Life
Humans
Kinetics
Male
Middle Aged
Phenotype

Source

Open in PubMed

Identifiers

PMID: 22274722
DOI: 10.1160/TH11-10-0719

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