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Article

Altered Neuronal Support and Inflammatory Response in Bipolar Disorder Patient-Derived Astrocytes

7 Mar 2021

Abstract excerpt

Bipolar disorder (BD) is characterized by cyclical mood shifts. Studies indicate that BD patients have a peripheral pro-inflammatory state and alterations in glial populations in the brain. We utilized an in vitro model to study inflammation-related phenotypes of astrocytes derived from induced pluripotent stem cells (iPSCs) generated from BD patients and healthy controls. BD astrocytes showed changes in...

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Share to Adenosine and Purinergic Signaling
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PMID: 33667413
DOI: 10.1016/j.stemcr.2021.02.004

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